Starts for Louw, Van der Merwe
Lock Flip van der Merwe replaces the suspended Eben Etzebeth while Bath's Francois Louw comes in for Marcell Coetzee on the openside flank.
There are four more changes on the bench, where Coetzee joins Dean Greyling, Andries Bekker and midfield back Juan de Jongh.
"The New Zealanders are good on the ground which is why we decided to go for a specialist openside flank in Francois," said Meyer.
"Marcell has been very good this season and has played a lot of rugby, but in this match we feel he will be more useful as an impact option."
Jannie du Plessis has been named at tighthead prop despite struggling with a hamstring niggle. Meyer said the Springboks' medical team is working very hard on the injured players and that Du Plessis will be given until Friday to fully shake off his injury, but if he fails to recover in time, Pat Cilliers will start.
"We will not take any chances with injured players and we have time to get him and Pat (Cilliers) match ready," said Meyer.
Greyling will be on the bench to provide prop cover, while Bekker takes over from Van der Merwe in the number 18 shirt. De Jongh comes in for Lwazi Mvovo on the bench.
South Africa: 15 Zane Kirchner, 14 Bryan Habana, 13 Jean de Villiers (capt), 12 Frans Steyn, 11 Francois Hougaard, 10 Morne Steyn, 9 Ruan Pienaar, 8 Duane Vermeulen, 7 Willem Alberts, 6 Francois Louw, 5 Juandre Kruger, 4 Flip van der Merwe, 3 Jannie du Plessis, 2 Adriaan Strauss, 1 Tendai Mtawarira.
Replacements: 16 Tiaan Liebenberg, 17 Dean Greyling, 18 Andries Bekker, 19 Marcell Coetzee, 20 Johan Goosen, 21 Juan de Jongh, 22 Pat Lambie.
Date: Saturday, September 15
Kick-off: 19:35 (08:35 BST, 07:35 GMT)
Venue: Forsyth Barr Stadium, Dunedin
Referee: George Clancy (IRE)